How Mast Cells Use Neutrophils in Allergic Reactions

Mast Cells, Neutrophils, and Allergies

Mast cells are immune cells that are involved in allergic reactions. They release histamine and other mediators that cause symptoms such as sneezing, runny nose, and itchy eyes. Neutrophils are another type of immune cell that is involved in inflammation. They are attracted to the site of an allergic reaction and release cytotoxic mediators that can damage tissue.

A Surprising Discovery

Researchers have recently discovered a surprising interaction between mast cells and neutrophils in allergic reactions. They found that mast cells can trap neutrophils and use them to amplify the allergic response. This discovery could lead to new treatments for allergies.

How Mast Cells Trap Neutrophils

Mast cells trap neutrophils by releasing a sticky substance called interleukin-8. This substance attracts neutrophils to the site of the allergic reaction. Once the neutrophils are trapped, the mast cells release another substance called tumor necrosis factor-alpha. This substance activates the neutrophils and causes them to release cytotoxic mediators.

Implications for Allergy Treatment

The discovery that mast cells can trap neutrophils could lead to new treatments for allergies. By targeting this interaction, researchers may be able to develop drugs that prevent mast cells from trapping neutrophils. This could lead to a reduction in the severity of allergic reactions.